尼克劳斯(吸血鬼始祖与狼人的混血)在新奥尔良回到他的过去， 得到一个对他正在酝酿阴谋的神秘提示下， 尼克劳斯回到了那个他和他家人帮助建立起的美国南方大城，新奥尔良(New Orleans)。尼克劳斯的疑惑导致了他和他前门徒马赛尔的团聚， 马赛尔是一个对新奥尔良所有人类与超自然生物有着绝对控制权的魅力吸血鬼。以利亚(吸血鬼始祖，尼克劳斯的哥哥)决心想要帮助他的弟弟尼克劳斯找到救赎， 他追随着尼克劳斯并很快发现海莉(狼人)也来到了这个法国区寻找她家族历史的线索但是她落在了一个强大的女巫苏菲手上。 而此时尼克劳斯发誓要在新奥尔良夺回属于自己的权力，取代前任，成为这里的王者。

《初代吸血鬼》英文台词

　　Sir, would you be so good as to tell us

　　where it is that we have arrived?

　　The French colony of Louisiana

　　off the shores of a town they've named New Orleans.

　　Always and forever, Rebekah.

　　That is what we once swore to each other.

　　Consider this me calling take-backs.

　　Oh, you've called take-backs dozens of times over the centuries,

　　and yet when our father found us

　　and chased us from this very city...

　　I may be old, Elijah, but I'm hardly senile.

　　I know very well I stuck with Klaus,

　　and not 3 years later, he stuck a silver dagger

　　in my chest and sent me into a magical slumber for 90 years.